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Pilot studies demonstrated elevated levels of plasma DNA methylation years before diagnosis.
Some studies demonstrated elevated levels of these cytokines in jugular vein during acute migraine attacks, however, there were discrepant results with respect to the determination of serum levels of cytokines in migraine patients [3 6].
Our previous studies demonstrated elevated plasma concentrations of fibulin-1 in diabetic patients [ 1].
Additional studies demonstrated elevated miR-210 expression in other carcinomas, such as pancreatic cancer, glioblastoma, head and neck cancer, and renal cancer [ 17– 20].
Previous epidemiology studies demonstrated elevated lung cancer mortality in coal-mining areas of Appalachia, suggesting that environmental contaminants from coal-mining activities may contribute to the increased lung cancer risk.
Some studies demonstrated elevated levels of miR135a in colorectal tumor cells [ 20] and others identified miR135a as regulator of the tumor suppressor gene adenomatous polyposis coli (APC) with a potent effect on Wnt pathway activity.
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Several studies demonstrate elevated adenosine levels in patients with chronic lung disease.
Overall, these studies demonstrate elevated body burdens of Hg in exposed populations such as miners, workers involved in ore processing, and even children residing in mining communities.
An earlier study demonstrated elevated IACFM pressures were associated with enhanced cellular responses [ 18].
This study demonstrated elevated health care resource use and costs in patients with COPD after acquiring pneumonia compared to those without pneumonia.
Regarding the roles of these miRNAs in immune response, a previous study demonstrated elevated miR-142 in systemic lupus erythematosus patients compared to healthy controls [ 68].
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