Twenty interventional studies comprising 2667 participants were included.
106 studies comprising 301 effect sizes were analyzed.
A systematic search identified and included 19 clinical studies, comprising 1620 participants, and 12 non-clinical studies, comprising 2137 participants, published between 1986 and 2014.
The remaining six studies, comprising 718 patients, utilized ambulatory 24-hour pH testing to determine abnormal GER.
A total of 28 studies (comprising 54 fasted and 22 postprandial comparisons) were included.
Eleven studies comprising 11,070 cases and 19,169 controls were included in this meta-analysis.
Our approach was applied to several case studies, comprising a total of seven benchmark circuits.
Eighty-one unique studies comprising 31,794 school students met inclusion criteria.
Results: A total of 14 studies, comprising 15 comparisons, met the inclusion criteria.
Nineteen controlled and six single-arm cohort studies comprising 1086 patients met the inclusion criteria.
PubMed and Scopus databases were queried, and 12 studies comprising 266 patients were analyzed.
