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However, these nonclinical safety assessment studies can detect these effects if properly designed and conducted using appropriate instrumentation.
Post-marketing studies can detect adverse effects that occur rarely or because of extended intake, because administration occurs in a larger timeframe and study population than in the phase I-III clinical trials.
While re-sequencing studies can detect large numbers of singleton SNPs in many population samples (depending on population history), the selection of informative SNPs for genotyping studies (i.e., ascertainment) ensures that most SNP marker alleles will segregate at intermediate frequency, exaggerating the difference in frequency spectrum that already exists between SNPs and SSRs [3], [4].
However, such studies can detect spurious QTL due to linkage disequilibrium or bias generated by the experimental design [ 44, 45].
Small cohort studies can detect only large increases in the risk of specific congenital abnormalities and are limited in their ability to provide an assurance of safety.
Such validation studies can detect the various components of variability of a biomarker and indicate needed improvements of the assay, along with possible use in field studies.
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The primers sets designed in this study can detect hantaviruses from almost all known genetics lineages in Brazil and from others South America countries and also increases the possibility to detect new hantaviruses.
The devices designed in this study can detect 2 Ab within a linear range of 11.2 μg/mL to 112 μg/mL, and the detection sensitivity and R-square are −0.64 A/(g/mL) and 0.896, respectively.
The ELISA kit used in this study can detect all circulating TWEAK in sera.
The different analyses performed in this study can detect significant associations with different features.
The screening study can detect low-grade scoliosis, even in children in whom previous deformities had gone undetected.
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