We had the opportunity to test the hypothesis that Gln267 may play a relevant role in the recognition of huCollp261 by the TCR under study, by stimulating in parallel PBMC from patient OE with a peptide encompassing a subdominant epitope of the same protein, namely peptide huCollp289 303 (sequence GKRGARGEOGGVGPI, where O is hydroxyproline, Hyp).
The functional consequences of the presence of the DECTIN-1 Y238X polymorphism on cytokine production capacity of macrophages were studied by stimulating the cells with β-glucans.
Back in Washington DC, Hammond's vision was as clear and Osborne's is smoggy: The world is moving towards a low carbon economy; I would suggest that there may now be more risk in being left behind than there is in taking the lead... Studies suggest that by stimulating greater innovation and efficiency, climate policies will increase our economic competitiveness.
"This study proves that by stimulating peripheral nerves and muscles, you can actually 'retrain' the brain," says the study's lead author, Dr. Milos R. Popovic, a Senior Scientist at Toronto Rehab and head of the hospital's Neural Engineering and Therapeutics Team.
A dog model was developed to study visceral pain by stimulating the ovarian ligament.
We then studied evoked responses by stimulating the stump of the dorsal root or dorsal root entry zone in spinal cord slices, or the spinal trigeminal tract in CSTN slices.
Previous studies supported this hypothesis by stimulating flies with movies presenting the visual input they would perceive during flight in a box (Kern et al., 2005; van Hateren et al., 2005; Kern et al., 2006; Karmeier et al., 2006; Liang et al., 2008; Liang et al., 2012).
In the meanwhile, however, we believe that sharing the current proposition can promote deeper understanding of healthcare system transitions and optimization of patient-centeredness by stimulating investigative studies and discussions.
Depending on further methodical developments, futures studies may even investigate such issue by stimulating 2 distinct TMS sites concurrently or in series, with multiple TMS coils during concurrent fMRI, to study the impact of perturbations at multiple loci during spatial attention.
Researchers can also crucially play a role in policy learning, by engaging with other health system actors directly to support them to reflect on and rethink existing problems (Case studies 2 and 3), or indirectly by stimulating public debate and opinion [ 31].
