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Although these studies are large and comprehensive, have they advanced from the early recognition of traditional risk factors to become relevant in the current complex research environment?
First, the protein complexes she studies are large and dynamic, have transient interactions, and are present in low numbers within cells, all of which makes them hard to isolate in sufficient quantity and purity, Sharon says.
Both studies are large and data acquisition was prospective, but the studies are purely observational.
Phase III studies are large, confirmatory studies that state prior hypotheses, potentially based on earlier phase II results.
In addition, not all published studies are large population-based studies and variations in sampling techniques may bias measures of disease occurrence.
With the piling number of options for phase III trials of HRPC, and overall survival being the only accepted end point, such randomised studies are large and lengthy.
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We found 117 papers; 7 studies were large cohort studies from diverse populations (Table 1), and therefore, were suitable for our review.
The effect sizes in both studies were large and consistent.
For Crohn's and UC, both studies were large retrospective surveillance studies.
The heterogeneity in healthcare costs across studies is large (I= 93.0%).
However, discrepancy between observed to expected mortality amongst individual studies is large.
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CEO of Professional Science Editing for Scientists @ prosciediting.com