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Case control studies are frequently used in sepsis research.
Suboptimal enhanced vascular studies are frequently encountered in imaging, either due to technical or patient factors.
Functional MRI studies are frequently based on the BOLD (blood oxygen level-dependent) effect.
For example preclinical studies are frequently small and there is often substantial heterogeneity between studies.
Clinical research studies are frequently confounded by a lack of agreed definitions and consistency of testing.
The data collected in epidemiological or clinical studies are frequently clustered.
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Methodological appraisal of the primary studies is frequently hindered by lack of information.
Studies were frequently limited though, in quality of design and implementation.
4 5 Included studies were frequently associated with methodological weaknesses that limited the validity of the reported findings.
The observed impairment of fetal growth in these studies is frequently attributed to direct effects of glucocorticoids on the fetus.
In scenarios where the hypothetical treatment had no association with mortality, or scenarios when the treatment was truly effective, studies were frequently unable to measure its true effect.
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