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In each human cell line studied, repressive histone modifications, such as H3K9, H3K27 and H4K20 methylation, were also accumulated at multiple satellite arrays, such as alpha satellite, HSAT4 and gamma satellite.
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H3K9m2 and H3K9m3 are well-studied repressive marks that are enriched in compacted heterochromatin [ 42, 43].
A less well-studied repressive histone mark, H1.4K27me, is also reported to be demethylated by all KDM4 members [ 22].
In that study the repressive effect was studied using both the luciferase reporter and exogenous miR29b constructs in transfected HEK293T cells, whereas we studied the exogenous reporter constructs in the natural neuronal milieu.
Two gene silencing phenomena, PEV and PcG repression, have been extensively studied and their analysis has provided insights into two distinct repressive mechanisms employed in most eukaryotes.
To examine whether CpdA exerts its repressive activity via the GR, we studied regulation of matrix metalloproteinase 13 (MMP-13) in mouse embryonic fibroblasts (MEFs).
Similarly, the interplay between activating trimethyl marks and the repressive PRC2-dependent methylation at Lys27 was studied using site-specifically modified mononucleosomes.
The mine provides a European case study to examine the repressive techniques deployed by RWE to legitimise coal mining in the face of a determined opposition.
In the repressive Communist society, Mr. Smirnoff's impudent humorous spirit manifested itself early, and though he studied art, he was determined to become a comedian.
We studied histone marks associated with the IL3 promoter region because this gene is under the direct repressive control of AML1/ETO, and it is critical for myeloid maturation.
To better understand the repressive effect of TFAP2A on DCBLD2/ESDN transcription, the interaction of TFAP2A with other co-factors will be studied in the future.
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