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The Levine lab has studied mechanisms responsible for switching genes on and off in the early Drosophila embryo for over 30 years.
Michael Levine's lab has studied mechanisms responsible for switching genes on and off in the early Drosophila embryo for over 30 years.
Based on observations and correlations alone, we also cannot offer physical mechanisms for the relationships we demonstrate, though our analysis is consistent with previously studied mechanisms on how a warmer Arctic can influence mid-latitude weather5,6,15.
Here, we examine what is known of one of the most extensively studied mechanisms of cellular drug resistance.
Though protein biosynthesis, transport, and quality control in the ER have been extensively studied, mechanisms underlying the heterogeneous architecture of the ER have been clarified more recently.
Oxidative DNA damage is one of the most significant and extensively studied mechanisms of neurodegenerative diseases such as Parkinson and Alzheimer.
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In addition to these well-studied mechanisms of cancer drug resistance, recent studies have linked the acquisition of cancer drug resistance to altered expression of microRNAs (miRNAs; Kovalchuk et al. 2008; Liang et al. 2010; Pogribny et al. 2010; Zhao et al. 2008).
This fact challenges standard evolutionary explanations of prosociality because well-studied mechanisms of cooperation based on genetic relatedness, reciprocity and partner choice falter as people increasingly engage in fleeting transactions with genetically unrelated strangers in large anonymous groups.
Well-studied mechanisms by which environmental exposures result in cancer include causing DNA damage, eliciting inflammatory responses, and disrupting endocrine function.
In prokaryotes, there are well-studied mechanisms that mediate gene transfer, both within and across species boundaries 57.
A few of the pesticides used at our agricultural sites cause endocrine disruption and have well-studied mechanisms of toxicity.
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