Similar(60)
Simulation of the metabolism of these three steroids across a full dose response range of PCN or LCA demonstrated no impact on the Km for testosterone, progesterone or cortisol metabolism by CYP3A1 in the stubborn PXR system versus the full network.
The relative Vmax in the stubborn PXR system, as a percentage of the Vmax in the whole network, was calculated and is shown in Figure 7: Interestingly, the resultant histogram for PCN treatment is biphasic, with the lowest point between maxima occurring at the Kd of PCN for PXR (∼1 µM).
Officials warned that a Stage 3 emergency, which has never been declared, was possible because a stubborn high-pressure system stretching from Mexico to Canada had kept temperatures so high that air-conditioning systems were working harder and longer throughout the entire region.
But the forecast, dominated by a stubborn high-pressure system camped over New Zealand's North Island, remains sketchy.
The Alabama court system's stubborn and myopic focus on deadlines was actually part of a larger national trend.
Mechanical delays can be caused by a range of issues, not all of which are critical; we've experienced these setbacks for everything from safety issues (a fire detector in an engine failing) and instrument glitches (a cockpit display simply not powering on) to a stubborn in-flight entertainment system (the seat-back TVs refused to turn on).
Severe weather problems in our major agricultural areas, uncertainty in the European and United States financial systems, a stubborn low-growth economic environment, instability in the Middle East that threatens energy supplies, and slower growth in China and Asia all spell the pressing need for a reliable and trustworthy risk management industry.
Despite the other medical assaults on his body — diabetes, hypertension, hepatitis C, stubborn leg ulcers — his immune system remained intact.
Sylvester Turner, mayor of the nation's fourth-largest city, told residents to stay home to fend off a weather system he called "stubborn".
It means that you are troubled by the stubborn persistence of our class system, though you personally have done fine by it.
Overall, the Russian innovation system appears to be stubborn to changes, which are hindered by path dependency and belief in exclusively federal support.
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