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The structures of the several extracellular membrane-proximal domains and the transmembrane helix of plexins have not been determined.
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Mr. Jaczko also offered a new theory about the cause of the explosions that destroyed the secondary containment structures of several of the reactors.
In addition, the availability of the crystal structures of several proteins of the CHIKV RNA genome and other related alphaviruses is encouraging the drug discovery process through target structure-based pharmacophore modeling, virtual library screening, and drug docking approaches.
The structures of the complexes in several pil mutants were determined.
The solid-state structures of several of the catenates show interligand aromatic-stacking interactions which are a feature of benzylic amide catenanes and rotaxanes and serve to favor the assembly of the interlocked structure rather than macrocyclic isomers.
The 3-D structures of several complexes between the various p53 regions and unique binding partners have been determined (see Figure 3).
This has resulted in the crystal structures of several members of the KIR family and more recently the determinations of the three dimensional structures of KIR2DL2 and KIR2DL1 complexed with their respective ligands, HLA-Cw3 and HLA-Cw4.
Accordingly, we have used cryo-EM to determine the structures of several conformations of the CrPV-IRES/ribosome complex at resolutions beyond 4 Å, which allowed us to build and refine complete atomic models for the complex.
In parallel, they observed a highly overlapping between the motifs in the pharmacophore and those found in the crystal structures of several inhibitors of the viral protein 35.
The crystal structures of several members of the MarR family show that the winged HTH DNA-binding core is flanked by helices involved in protein dimerization [71], [72].
By the year 2000 we had the structures of several oncogenic mutants and the Ras/GAP complex revealing the transition state of the GAP-catalyzed reaction.
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