Exact(1)
Definitive proof of the "toxic oligomer" hypothesis has yet to emerge, however, hampered by a critical lack of clarity regarding the mechanism of neuronal toxicity and the structures of the diverse array of nonfibrillar assemblies of Aβ formed in vivo and even in vitro, motivating efforts to characterize the structural details of the assembly process.
Similar(59)
The central logic to the dynamic operational structure of these diverse systems lies within the stable redox proteome linked to NADH/NAD+ and NADPH/NADP+ metabolism.
On top of this inter-continental trend, there is a variety of population structures in the diverse endemic foci of Southeast Asia [21], [25] and South America [21], [24], and evidence that continental Africa may contain some populations with a relatively low effective recombination rate [22], [26].
To understand these results at atomic resolution, we obtained x-ray co-complex structures for nine of the diverse ligands and for all six phenol analogs.
Phylogenetic and population structure of the 285 diverse panel.
The population structure of the extraordinarily diverse Bamar differed substantially from that of the Karen people who displayed signs of genetic isolation.
The population structure of the extraordinarily diverse Bamar differed from that of the Karen people who displayed signs of genetic isolation.
The size structure of the genetically diverse prey populations diverged from single strain populations in the presence of predators, showing increases in colony size and in the relative abundance of cells found in colonies.
A further dataset was manually curated from the PDB to guide the generation of a map of the structures of diverse and therapeutically relevant potential small molecule binding sites.
Structures of the Arf GAPs are diverse containing catalytic, protein protein interaction and lipid interaction domains in addition to the Arf GAP domain.
What principles govern and determine the occurrences of the diverse structures in Mayrinax linking constructions?
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