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Large efforts have been made to elucidate the structure of coatomer over the years, including several crystal structures of fragments of the seven subunits (Jackson et al., 2012; Lee and Goldberg, 2010; Ma and Goldberg, 2013; Suckling et al., 2015; Yu et al., 2012), and electron microscopy (EM -based rEM -basedtion of the entireconstructionf coftheentiredonova et al., 2015; Yip and Walz, 2011).
Structures of fragments of Tec family kinases in the Protein Data Bank.
This is illustrated by the crystal structures of fragments 44, 48, and 60.
We obtained crystal structures of fragments from two distantly related cell-adhesion GPCRs (CL1 and BAI3) that include the GAIN domain and, additionally, the HormR domain.
Several structures of isolated domains of Btk have been determined previously, as summarized in Figure 1 source data 1, which also lists structures of fragments of other Tec family kinases.
Towards this end, we here determined the crystal structures of fragments containing the GPS motif, the stalk region and the HormR domain from two distantly related cell-adhesion GPCRs, CL1 and BAI3.
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These interactions were predicated on the intermolecular packing arrangements observed in crystal structures of fragment D from fibrinogen and the D-dimer isolated from cross-linked fibrin.
Tandem mass spectra of protonated 4,4′-MDA, 2,2′-MDA, and 2,4′-MDA are presented in Figure 2d f, and potential corresponding structures of fragment signals are shown in Table 1.
The pore structure of fragments of steam reforming catalyst ring-shaped pellets was characterised so as to simulate a larger particle using larger pore networks comprising millions of pore segments.
To predict the secondary structure of fragments of rRNA, we used our massively parallel genetic algorithm, MPGAfold, involving populations of thousands of structures [48] [51].
Unfortunately, the structure of fragments of only two COG subunits have been reported [ 61, 63], hampering us to analyze with more detail the evolution of distinct regions of each protein.
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