The use of dense meiotic maps has proven to be a powerful framework for study of genomic architecture and spatial structure of divergence in natural populations (Bradbury et al. 2013; Gagnaire et al. 2013b).
Because development of Lewy pathology is facilitated more or less by such "structural template", gradients in lesion density could be determined by the relative propensity dependent on underlying structures (degree of divergence of axon, for example), influence of mitochondrial stress, or energy expenditure.
Genomes of such hybridizing species may be expected to exhibit a mosaic structure, with high levels of divergence restricted to "speciation islands," which contain the loci responsible for species differences (Wu 2001).
Our analysis of sequence conservation within the receptor structure revealed a striking degree of divergence in a considerable portion of the NTD – the region of C family GPCRs responsible for ligand binding [ 19, 50].
The combined effect of these different processes has likely given rise to the patterns of divergence and structure observed on Réunion, which are remarkable given the small geographic scale of the island and thus the opportunity for high levels of homogenizing gene flow in a highly vagile organism.
Their non-metallicolous and metallicolous populations are often sympatric thus providing an ideal opportunity for comparative estimation of genetic structures and divergence under the selective pressure derived from copper toxicity.
Clearly, JTT is unable to conserve structure even for relatively low amounts of divergence: at Ka = 0.28 only 20% of sequences obtained from JTT simulations recognize the correct structure.
However, the significant pattern of divergence of intron structure between classes, and conservation within classes, adds further evidence for functional divergence among classes.
This might be due to the greater extent of divergence of this structure between mice and men than other CNS regions, like the cerebellum and retina.
However, the cerebral cortex has the lowest percentage of shared DHSs of the regions analyzed, possibly reflecting the greater extent of divergence of this structure between mice and men.
