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He planned a book on the discovery of the structures of cellular macromolecules but soon broadened his focus to embrace the history of molecular biology, and this became his project for the next decade.
Structural biological methods are available for obtaining molecular structures with atomic resolution, and tremendous progress is being made in solving the structures of cellular proteins and protein complexes.
Here we reconstruct phylogenies describing the evolution of proteomes and protein domain structures of cellular organisms and double-stranded DNA viruses with medium-to-very-large proteomes (giant viruses).
For example, concentrated VSV-G-pseudotyped LV vector preparations were shown to be contaminated with tubovesicular structures of cellular origin which carried nucleic acids, including the plasmid DNAs that were used to generate the LV vector stocks.
The single-particle approach to cryo-EM, which emerged in the late 1970s (Frank et al., 1978; van Heel and Frank, 1981), offered the possibility of being able to determine the atomic structures of cellular machinery without the need for crystals, as required for X-ray crystallography.
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Cashikar, A. G. et al. Structure of cellular ESCRT-III spirals and their relationship to HIV budding.
Metabolic oligosaccharide engineering is powerful approach to altering the structure of cellular sialosides.
The structure of cellular and syncytial tissues and the formation of specialised intercellular junctions are described.
Cell morphology was assessed by scanning electron microscopy for differences in the structure of cellular interaction.
They are harmful because they tend to interact strongly with nearby molecules, changing the structure of cellular components such as DNA.
Consequently, engineering genes that protect and maintain the function and structure of cellular components can enhance tolerance to stress.
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