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Based on the phase contrast images and EDPs simulation of the microstructures of the transformed structures, a mechanism for the phase transitions of Ti2AlC is proposed.
On the basis of the different conformations of the invariant glutamine in the crystal structures, a mechanism called "glutamine switch" was proposed for differentiation of the substrates by PDEs [18].
Previous studies by the author and colleagues used 3D culture showed that when SUM149 cells were directly co-cultured with human monocytes U937 or in U937-CM, SUM149 became more invasive and formed branched like structures, a mechanism that was modulated by an increase in proteolytic activity and caveolin-1 expression of SUM149 [ 41].
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Visualized structures suggest a mechanism for nucleation of topological transitions underlying the reshaping of DNA by bacterial nucleoid-associated proteins.
Together with in vitro studies, the crystal structures suggest a mechanism for ANS-catalyzed anthocyanidin formation from the natural leucoanthocyanidin substrates involving stereoselective C-3 hydroxylation.
The structures reveal a mechanism of cooperativity between the two PAM2 sites that increases the binding affinity but prevents the binding of more than one molecule of eRF3 to PABPC1.
Meta-analysis of a number of structures produced a mechanism in which the E and F helices had strong interactions across the dimer interface allowing a small rotation but no translation within the interface during the allosteric transition.
These observations suggest that p85β regulates invasion by priming formation of invadopodium-like adhesion structures via a mechanism involving GTP-Cdc42/Rac recruitment to cell adhesions, which mediate actin polymerization.
In order to control the complexity of the proposed structures, a regularization mechanism could be investigated.
Based on the complex structures, a catalytic mechanism of FamD1 is proposed.
On the basis of these and other structures, a molecular mechanism is proposed for the activation of adenylyl cyclase by Gs α.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com