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For chromium and ginseng, he found no scientifically structured trials that showed a difference in weight loss between the supplement and a placebo.
Epinephrine for treatment of cardiopulmonary arrest became commonly used more than four decades ago with support of observational and theoretical information rather than structured trials.
Systematic trawling of massive databases held by government payers and private health insurers might also show up problems that individual doctors and patients might not necessarily associate with a particular drug.Such signals would still need to be followed by structured trials in the marketplace.
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But the agency refused to consider the application because the company had structured its trials poorly and had failed to collect necessary data.
She suggests a series of reforms in the way the F.D.A. is structured, clinical trials are conducted, and drug marketing is handled, all of which are very good ideas, but almost none of which will make the slightest difference in the prescription-drug problem.
The field experiments in the different locations were structured into trials.
Two identical skin and skin structure trials, ATLAS I and II, compared telavancin 10 mg/kg/day to vancomycin 1 g every 12 hours and found telavancin to be non-inferior to vancomycin [ 63].
If these events occur with no phase relationship to the task structure, trial averaging will destroy their temporal structure and we will not be able to distinguish these events from overall higher baseline activity.
Further well structured randomized clinical trials are necessary to reach any conclusive answers.
Daily structured spontaneous breathing trials, with interruptions of sedation and optimization of underlying conditions, are the quickest way to assess readiness for extubation [ 49].
In addition, for structure-modification trials, structural progression should be measured by radiographic changes.
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