Gabapentin is recommended as a first-line drug in the treatment of neuropathic pain, and has recently been demonstrated to act on supraspinal structures to stimulate the descending noradrenergic pain inhibitory system.
The ability of G4 structures to stimulate FEN1 and EXO1 not only identifies these enzymes as key to stability of regions bearing the G4 motif, but also raises the further possibility that the G4 motif may confer special localized properties in replication or recombination.
Strong similarities between the sequences in the gag-pol region of MuLV and the other viruses of the readthrough retrovirus group imply that the other readthrough retroviruses may use a similar pseudoknot structure to stimulate the stop codon readthrough as well [ 22, 23].
In design processes, these insights can be used to structure consumer insights, to stimulate creativity, and to support communication within the design team, with clients and with consumers.
The key purpose of structuring knowledge is to stimulate idea generation based on a fundamental and general understanding of underlying mechanisms.
Synthetic oligodeoxynucleotides that mimic gram-negative bacterial REP unit sequences and their secondary structures were shown to stimulate the mammalian immune system via Toll-like receptor 9.
Several new nanostructured macroporous materials are being designed to mimic tissue structure and properties, and to stimulate new tissue growth while degrading in the body.
Even though this might not be directly obvious from our current departmental structure, we particularly want to stimulate research and invite submissions at the interface of multiple functional areas within Business Administration.
Writing in the British Medical Journal, psychiatrists stated, given its chemical structure, "mephedrone is likely to stimulate the release of, and then inhibit the reuptake of monoamine neurotransmitters".
Moreover, transgene cassette and capsid structure have been shown to stimulate an immune response [ 171, 172].
