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All participants were asked to complete a structured Chemotherapy KAP Questionnaire and QOL Questionnaire at pre- and poststudy time.
A structured Chemotherapy KAP Questionnaire was developed on the basis of [ 14, 15], which consisted of 3 dimensions (knowledge, attitude, and practice) (the Chemotherapy Knowledge-Attitude-Practice Questionnaire is shown below).
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The presence of T-bet+ lymphocytes in peritumoral lymphoid structures after chemotherapy was significantly more frequent in patients treated with trastuzumab taxane (P=0.0008).
However, in the present study, we did not observe a significant T-bet induction in intratumoral lymphoid structures after chemotherapy in patients treated with an anthracycline-based regimen.
We provide flexible structures for chemotherapy and radiotherapy schemes that adapt to the patient's individual case/stage and focus on other conditions during treatment process.
The promise of novel stem cells-based therapies, such as therapies for impaired organs, degenerative diseases (Ehnert et al. 2009; Gratwohl and Baldomero 2009; Macarthur et al. 2009) or reconstitution of blood structure after chemotherapy in treatment of leukemias (Marciniak-Czochra and Stiehl 2012), has led to increase of interest in this field.
By contrast, in patients treated with trastuzumab taxane, the presence of T-bet+ cells in peritumoral lymphoid structures after chemotherapy (P=0.02; HR: 5.6; 95% CI: 1.25 25) and T-bet+ cells induction (P=0.04; HR: 6.7; 95% CI: 1.08 38) were associated with a better RFS (Table 2).
Well structured.
Our data demonstrate a decrease in glucose metabolism in both gray and white matter structures associated with chemotherapy.
In this population, multivariate Cox regression model showed that only the presence of T-bet+ cells in peritumoral lymphoid structures after neoadjuvant chemotherapy was independently associated with improved RFS (P=0.04; HR: 4.76; 95% CI: 1.07 20) (Table 3).
In this population, multivariate Cox regression model showed that only the presence of T-bet+ lymphocytes in peritumoral lymphoid structures after neoadjuvant chemotherapy was independently associated with improved RFS (P=0.04).
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