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Among the statistically differentially expressed genes, changes were also found in the expression of genes involved in the pathways related to neuronal damage, Ca2+ regulation, gliosis, inflammation, synaptic transmission, and cytoskeletal structure (Tables 3 and 4).
Although the binding mode of ZM241385 – the synthetic antagonist co-crystallyzed with the A2A receptor – shows some dissimilarities when compared to carazolol and retinal, the binding pocket identified by our key positions matches that indicated by the crystal structure (Tables 2 4) The natural ligands of class A GPCRs bind extracellularly to large soluble N-terminal ectodomains, i.e. the GPHRs.
For each of the 100 ligands under study, we obtained a local minimum conformation with an mwRMSD of <1.00 Å relative to the ligand conformation in the crystal structure (Tables 1 and S1) when using the NEM procedure, the conjugate gradient minimization method, and a gradient cut-off of 0.06 kcal/(molÅ).
Bacterial counts decreased with increase in well distance from sanitary structure (Tables 3, 4, 5 and 6).
Similarly, outlier behavior was explored using a variety of approaches including FST-based estimates of population structure (Tables 2 and 3) and Bayesian clustering analyses (Fig. 3).
Our results showed higher protective properties for anthocyanidins and flavonols than for hydroxycinnamic acids, being associated with their chemical structure (Tables 4, 5, Fig. 2).
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The method is based on transformation of FSM structure table and replacement of some logical conditions.
Based on the integration study of the existing standards, the structure table of engineering construction standard is put forward.
The method is based on encoding of the rows of FSM structure table and replacement of logical conditions.
Eventually we solved the structure at 3.6-Å resolution by molecular replacement, using the K-8794-bound K-8794-bound K-8794-boundd Fig. 1a).
Finally, in total, 2277 distance restraints from NOE, 80 hydrogen bonds and 166 dihedral angle restraints for backbone φ and ψ angles were used to calculate solution structure (Table 1).
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