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At the same time, prior knowledge about the CM structure specificity could considerably enhance the processing efficiency and analysis precision due to a considerable decrease in the dimensionality of the parameter vectors involved into the adaptation process [13, 26].
It is essential that, taking into account the structure specificity of utilized matrices and vectors, it is possible to make signal processing in CS systems based on ML estimates (21) and (36) as well as their variants [30 32, 36, 37] less computationally consuming.
It has been observed that the dinucleotide relative abundance signature could discriminate local structure specificity more than sequence specificity.
The enzyme exhibited a hexameric quaternary structure, specificity for Mg-ATP as substrate and requirement of phosphate for its activity.
Using a heuristic algorithm particle swarm optimization (PSO), all the designed primers were computationally validated to fit the common primer design constraints, such as the melting temperature, primer length and GC content, PCR product length, secondary structure, specificity, and terminal limitation.
These families include GH38 configuration-retaining α−mannosidases and family GH47 inverting mannosidases, that together are the most studied of the known α−mannosidases, as well as enzymes in GH76 and GH92; the latter recently studied in the context of 3-D structure, specificity and catalysis [10].
Similar(44)
These binding sites may have low sequence specificities, but their binding affinities can be complemented by high structure specificities.
Therefore, we conclude that the sequence and structure specificities are both required and may play complementary roles during binding site recognition of SRSF1.
It is the most widely used structural alphabet and has been proved useful in approaching several problems in the area of structural bioinformatics, e.g., to compare protein structures [69], [70], [71], analyse sequence-structure specificities [72] or mine protein binding sites [73], [74].
HJ resolvases are typically small homodimeric endonucleases that bind with structure-specificity to the HJ and introduce a pair of symmetrically placed incisions in strands of like polarity at or close to the junction crossover point.
Target genes with the highest values of structure-specificity of the knockout effect (RankSpec) are shown in Table 2. From the table it can be seen that the gene NR3C1 has a maximum specificity to the cerebellum, i.e. the suppression of its expression leads to the effect on the expression of objective genes of "apoptotic process" GO category which is highly specific to this structure.
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