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A detailed knowledge of the mapping between sequence and structure spaces in populations of RNA molecules is essential to better understand their present-day functional properties, to envisage a plausible early evolution of RNA in a prebiotic chemical environment and to improve the design of in vitro evolution experiments, among others.
Other advantages come from the more life-like sequence and structure spaces of the vector world.
Although these model constructs are unrealistic in many respects, they do provide computationally tractable sequence spaces that can be mapped onto structure spaces with specified mapping rules.
This optimization has important consequences for evolution of molecular structure and the mapping of sequence to structure spaces, which represent different levels of biological organization.
The mutation rate also determines the spread of the population in sequence and structure spaces.
A more detailed view into these structure spaces will likely require continued experimental efforts as well as molecular dynamics simulations.
Similar(49)
The relatively limited number of structural designs suggests that structure space is finite and evolutionarily more conserved than sequence space [ 23, 27].
The Structure Space is the collection of structural fragments from which we can select the candidate structural fragments for a sequence segment.
The SSAP (Sequential Structure Alignment Program) method uses double dynamic programming to produce a structural alignment based on atom-to-atom vectors in structure space.
But Mr. Magloire faltered in attempts to play with form or to structure space.
He gets his mind around structure, space, program and image, making of them an integrated system.
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