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Two recent papers studying high-penetrance copy number variation at chromosome 16p11.2 find large changes in brain structure, refining hypotheses about the regions of the brain that are affected and implicating specific neurodevelopmental processes in these changes.
The mouse Slc11a2 sequence was used as query to generate the best structural models resembling templates present in the PDB using a threading approach, which combines tridimensional fold recognition by sequence alignment with template crystal structures and model structure refining (40).
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C The all-atom 3D structure refined by Amber energy minimization (1) To build the 3D virtual bond structure.
One structure (refined at 2.8-Å resolution) contains PRPP in all active sites, while the other structure (refined at 2.9-Å resolution) has PRPP in two sites and the hydrolysis products, ribose-5-phosphate and PPi, in the other sites.
We report a crystal structure refined to 3.6 angstrom resolution of the ribosome trapped with EF-G in the posttranslocational state using the antibiotic fusidic acid.
D Atomic probability map of the distribution of HPr with respect to EIN in the ensemble structure refined against intermolecular PRE data.
C Atomic probability map of the distribution of HPr with respect to EIN in the ensemble structure refined against intermolecular CXMS restraints.
At this point, we can structure (refine) a complex (composite) connector as an integrated set of simple connectors.
This correct behaviour unfortunately triggers many alerts when a structure refined with Olex2 is checked with PLATON.
The factor structure refined by exploratory factor analysis includes the error variance due to measurement error and a random component in the measured phenomenon.
Phase information was obtained by SAD using NdCl3 derivatized crystals and the structure refined to final Rwork/ Rfree values of 21.0%/25.7%.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com