In addition, studies show that the aromatic structures of tyrosine residues are important regulators of NP cellular uptake (referred to as the aromatic structure hypothesis) [63].
For example, crystal structures of tyrosine kinase peptide complexes have revealed a single binding pocket accommodating both the +1 and +3 residues (Bose et al., 2006).
Despite differences in structure, many of tyrosine kinases signal through the same pathways to typically enhance proliferation and prolong viability.
The 2.7 Å crystal structure of a tyrosine phosphorylated Dd-STATa homodimer reveals a four-domain architecture similar to that of mammalian STATs 1 and 3, but with an inverted orientation for the coiled-coil domain.
The crystal structure of protein tyrosine phosphatase B of Mtb origin was obtained from Protein Data Bank [PDB ID: 1YWF] [ 15].
The three dimensional structure of ErbB1 tyrosine kinase with compound POX (4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes) was downloaded from PDB (code number 3BEL).
But the binding sites of our new molecules were found to be a little different with comparison to reference inhibitor which is reported in the crystal structure of EGFR tyrosine kinase (PDB: 2J5F).
Hubbard SR, Wei L, Ellis L, Hendrickson WA, 1994, Crystal structure of the tyrosine kinase domain of the human insulin receptor, 1IRK ; http://www.rcsb.org/pdb/explore/explore.do?structureId=1irk, publicly available at the RCSB Protein Data Bank.
