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The effects of both variable groups, however, highly overlapped with the spatial structure of resistant levels, which suggests that a considerable amount of the effects attributable to both variable groups may be actually due to the spatial distribution of resistance.
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Of the isolates belonging to CC2, those in Clades ST570 and ST571 may have evolved in a unique manner in Vietnam because the structures of resistant islands in ST570 and ST571 isolates were different from those in ST2 isolates.
To deal with this, several directions have been explored since a decade: the structures of resistant proteins [ 3], second generation drugs that can bind resistant proteins [ 4], drug target polymorphism analysis in order to define "super drugs" [ 5], definition of new targets, such as protein backbones [ 6] or dimeric proteins' monomers, in order to block them before dimerisation [ 7].
The co-crystal structure of drug resistant cSrc-T338M kinase domain provides the structural basis of this activity.
PDB Description: structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation a2488c.
Description: Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation A2488C.
Crystal structure of multidrug-resistant (MDR) clinical isolate 769, human immunodeficiency virus type-1 (HIV-1) protease in complex with lopinavir (LPV) (PDB ID: 1RV7) showed altered binding orientation of LPV in the expanded active site cavity, causing loss of contacts and decrease in potency.
Our concomitant research focused on a detailed analysis of spoligotyping-based patterns (HGI = 0.595), underlying a more diverse population structure of drug-resistant M. tuberculosis isolates in Sichuan than in other parts of China [ 13].
Motion structures are assemblies of resistant bodies connected by movable joints.
The structure of the corrosion resistant layer was investigated before and after accelerated corrosion tests.
We report the first crystal structure of a drug resistant kinase in complex with an irreversible inhibitor.
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