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The chemical structure of glutamine is.
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Two structures of human glutamine synthetase represent complexes with: a) phosphate, ADP, and manganese, and b) a phosphorylated form of the inhibitor methionine sulfoximine, ADP and manganese; these structures were refined to resolutions of 2.05 Å and 2.6 Å, respectively.
These authors conclude that the positive effect of glutamine on intestinal structure after LPS endotoxaemia may be considered as a mechanism via which immunonutrition helps in the recovery of critically ill patients.
Based on the structure, it was suggested that exchange of glutamine 169 to arginine (as in MICA and ULBP3) may prevent binding by UL16 and therefore, could explain the specificity of UL16 for MICB and ULBP1 2 and 6.
The X-ray crystal structure of Ub (PDB: 1UBQ) shows glutamine 40 (Q40) oriented toward the C-terminus, and studies in yeast demonstrated that this residue can be substituted without deleterious effects on Ub function.
The activity of glutamine synthetase in different structures from the CNS was measured according to Dennis et al. [ 11] with minor modifications [ 12].
In strong contrast, a β-sheet structure of two helical turns (∼40 glutamines) is much more stable because it is joined together by hydrogen bonds between amides of successive turns.
In some clinical situations the endogenous production of glutamine may be insufficient to maintain optimal tissue structure and function such that glutamine becomes a conditionally essential amino acid.
The first series of peptidyl aldehyde inhibitors that incorporate in their structure a glutamine surrogate has been designed and synthesized based on the known substrate specificity of Norwalk virus 3C protease.
A low plasma glutamine concentration is the best indicator of glutamine depletion.
So far, low plasma glutamine concentration is the best indicator of glutamine depletion.
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