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The two phage genomes had a synteny in the structure module and shared many structural genes, while little similarity was found in the DNA replication/metabolism module.
BioJava (www.biojava.org) has a structure module, which handles input and output of standard PDB and mmCIF files, structural alignment using CE and FATCAT algorithms and access to CATH and SCOP.
The Structure module
As stated in the BioPython documentation for their structure module: 'A macromolecular structure is represented using a structure, model, chain, residue, atom (or SMCRA) hierarchy.
Constructing a human metagenomic network requires several sequential steps: (i) estimating pairwise similarity (or distance) measures between different taxa, (ii) adjacency matrix construction, (iii) network structure (module) detection and differentiated networks.
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In this respect, synthetic biological switches and sensors, as well as biological targeting or structure modules, have been employed to upgrade functions of polymers and solid inorganic material.
The protein structure modules provide tools for representing and manipulating 3D biomolecular structures, with the particular focus on protein structure comparison.
In opposition to these findings, Wang et al., by breaking down a PPI network into structure modules, found that the network is not functionally organized at the modular level and suggested it evolves neutrally [ 30].
A follow-up module, linked with the structuring module, allows the most adapted management, especially of the project resources.
Observed relationships between intron locations and protein structures (module boundaries) are used as evidence for the ancient origin of introns and for their role in exon/domain shuffling [ 20].
In structure-assembly approaches, RNA 3D structures are built based on the known structures modules ranging from fragments of 1 3 nucleotides to 2D structural motifs.
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