A utilitarian structure made of mismatched materials purchased for cheapness, the response to the new bridge was unenthusiastic; the Illustrated London News remarked at the time of its opening that "No attempt has been made to produce architectural effect, the structure being substantial rather than ornamental".
Regardless of whether the mode of action of Gcn5p is targeted or global, the effect of GCN5 on the chromatin structure of origins is substantial as shown in Fig. 5A.
Finally, these results suggest that there is substantial population structure separating populations north and south of the Sanaga River, but less population structure between populations within these regions, as expected based on previous studies [ 29].
We think denaturation is unlikely for the ectodomain because there is substantial helical structure and Tm > 100 °C.
Despite its widespread distribution along the east coast of Australia, there is substantial phylogeographic structure across the native range of the delicate skink.
Nevertheless, the studies thus far – irrespective of the approach used (common garden: [ 25]; QST- FST: [ 48]; population genetics or genomics: [ 33, 47, 51, 53, 58]) – suggest that there is substantial population structuring and local adaptation also in marine three-spined sticklebacks (but see [ 56, 60]).
Given the more conservative nature of the A328V and L437V mutations, these residues likely exert more subtle influences on active site structure, yet their impact on enantioselectivity is substantial (55% ee with P-I263F vs 99% ee with P-I263F-A328V-L437V, using 4-methylstyrene, Table 2).
There is substantial difference in the chemical structure and lipid solubility among ARBs [ 19].
3, 7 However, the speed of switching accompanying such structural changes is often quite limited, and their effects on macroscopic structures may be substantial.
"An anorak is substantial.
