Extensive resequencing identified several nonsynonymous mutations, and the detected effects on TGR5 structure, expression and function provide valuable insight into the structural biology of the receptor.
Such studies have shown that multiple changes in gene structure, expression and activity occur during tumorigenesis.
When it functions normally, all is well, but if its structure, expression or function is altered, some form of cancer results.
Tomasello, E. et al. Gene structure, expression pattern, and biological activity of mouse killer cell activating receptor-associated protein (KARAP)/DAP-12.
Structure, expression, and function of both types of peptidase-complex in P. falciparum are presently unknown.
Buxbaum JD, Lilliehook C, Chan JY, Go RC, Bassett SS, Tanzi RE, Wasco W, Blacker D. Genomic structure, expression pattern, and chromosomal localization of the human calsenilin gene: no association between an exonic polymorphism and Alzheimer's disease.
Nutrition genomics examines the role of nutrients and dietary components in regulating genome structure, expression and stability, as well as the role of genetic variation on individual nutrient requirements.
Characterizing relaxin-3 gene structure, expression patterns, and function in non-human primates and humans is critical to delineating its biological significance.
Using 'hits' from yeast display library screening, we evaluated the effect helix mutations have on structure, expression, stability, function (target recognition), and suppression of HIV entry.
(JPEG 2 MB) 40529_2014_9055_MOESM4_ESM.tiff Additional file 4: Figure S3.: Genomic structure, expression levels and morphology of AtBS14b knock-out mutants.
