Structure activity relationship studies and further structural elaboration afforded compounds with distinct activity profiles.
Further structure based elaboration of this residue resulted in a novel class of potent and selective inhibitors of uPA.
The activities involving the institutional level included, among others, the definition of appropriate organizational structures, the elaboration of a business plan for the plant's continuous operation as well as of strategies for a potential future multiplication of the applied technologies.
NMR can also be used to provide spatially resolved information about the binding site and orientation of the fragment hits that can be exploited to guide structure-based elaboration of these low-affinity start-points toward more potent and drug-like lead candidates.
This analysis identifies three core organising processes through which in situ simulation can act as a source of organisational safety: relational rehearsal, system structuring and practice elaboration.
We understand the demand for a better structuring and more elaboration.
Starring Simon Ward, the film efficiently depicted a young man's progress through his schooling, his experiences as a journalist in Africa (with a rousing recreation of the Battle of Omdurman in 1898) and his induction into Parliament, but it was given a complex flashback and narration structure, the sort of elaboration that was to mar Attenborough's later biography of Charlie Chaplin.
Further, in describing the degree to which actors are involved in cohesive groups that generate normative, symbolic, and cultural structure to behaviors, further elaboration of embeddedness measures could reduce ambiguity and provide actionable insights.
Although often interrupted by episodes of oligarchic or tyrannical rule and by periods of civic dissension and class rivalry, the main theme of governmental development in the Greek city was the elaboration of structures that permitted the control of political affairs by its citizens.
Synthesis may then continue, producing various core structures and their elaborations.
