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These results suggest the presence of early denaturation sites or denaturation nuclei whose local structure is disrupted prior to global structure disruption.
Logistic regression using SEN to predict structure disruption indicates that predicting which bases disrupt structure continues to be very difficult (AUC = 0.55).
We use three data sets to assess the difference between global versus local structure disruption, to evaluate different measures and to search for disruptive SNPs in human UTR.
A too high amount of FR leads to structure disruption and coalescence of grating features (see Figure 4 insets).
This mp-GR exhibits abundant carboxylic and/or hydroxide groups, edges, and defective sites due to the reaction and structure disruption caused by the hydrothermal treatment.
These phenomena might be because of the structure disruption of the liposomes when HFMF was applied to them and generate the releasing of DOX into the cancer site.
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Clearly, exposure to alcohol and trauma greatly affects all components of the intestinal physical barrier through changes in mucosal production and biochemical structure, disruptions of tight junction protein complexes, and increasing susceptibility to apoptosis in epithelial cells.
While normal cells in the human breast are organized into acinar structures, disruption of the acinar architecture is a hallmark of cancer.
The cells were chilled and maintained in an ice bath during cell-structure disruption in a Branson 450 sonifier (400W).
These findings suggest a mechanism for the occurrence of hypercontraction, muscle-structure disruption and lower-limb paralysis in affected mice.
These changes are predictably exacerbated in the type IIb fibers of homozygous mice, in which the embryonic myosin isoform is fully replaced by MYH4L342Q, leading to a hypercontraction, muscle-structure disruption and lower-limb paralysis.
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