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Zhang, Y. & Skolnick, J. TM-align: a protein structure alignment algorithm based on the TM-score.
The regions in the sequence alignment do not align in the structure alignment at all.
The sequences are aligned by way of multiple structure alignment program.
Structural superpositioning was accomplished using the secondary structure alignment approach and the program SSM Superimpose.
Krissinel, E. & Henrick, K. Secondary-structure matching (SSM), a new tool for fast protein structure alignmatchingthree dimenSSMns.
The FoldMiner web server (http://foldminer.stanford.edu/) provides remote access to methods for protein structure alignment and unsupervised motif discovery.
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Instead it exploits information on sequential and structural similarity directly by using sequence-structure alignment.
The alignments were manually curated for ambiguously aligned sequences compared to the 3D-structure alignment.
A mathematically straightforward iteration scheme provides a self-consistent optimum global sequence-structure alignment.
Sequence-structure alignment can be used as an alternative search strategy.
All other applied analyses were computed only on the sequence part of the sequence-structure alignment.
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