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An example is provided from the authors' current project, which involves structurally modeling the Turritella terebra seashell and conducting parametric studies to determine which of its characteristics allow for its adaptability.
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By using PRISM, we predicted the structures of the PPI interfaces and 40 additional interactions were structurally modeled.
The multipliers are structurally modeled in Verilog HDL.
We anticipate that researchers will utilize our tool to explore the predicted binding mode of kinase inhibitors with structurally modeled mutant kinases.
Additionally, the binding to a peptide EEVD motif, which is present in both Hsp70 and Hsp90, was studied by isothermal titration calorimetry and hydrogen/deuterium exchange and the interaction pattern structurally modeled.
Because of this similarity, the RT domain of HP has been structurally modeled using HIV RT as a template.
Among 387 residues that were structurally modelled, the "2009 H1neuraminidasediffersfroms from the other two in 21 positions.
A number of studies, in which AS isoforms were structurally modeled, have yielded insight into the impact of AS on the stability and function of proteins (see e.g. [ 7- 9]).
DUSP-UBL domains mediate some enzyme-substrate interactions [ 9, 33– 35] and confer intrinsic regulatory capacities that have been structurally modeled for mammalian USP4, USP15 and USP11 [ 20, 32, 35, 36].
In addition, the DAT N-terminal domain has been structurally modeled to identify the locations of positively charged patches that interact with negatively charged signaling lipids [phosphatidylinositol 4,5-bisphosphate (PIP2)].
Using facets to structurally model constraints, as well as functions results in clean, focused structural specifications.
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