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These two areas have few faults and were structurally located in peripheral areas of the paleo uplift at the depositional stage, so they are considered favorable plays for lithologic reservoirs.
Leu118 surprisingly did not affect syntaxin binding; yet, this amino acid is structurally located within domain 1 and mutations in this region have been shown to affect binding to the N-terminus of syntaxin [16], [44]-[46].
Complex care programs structurally located in tertiary care centers offer important benefits, including access to various specialists and services, and the ability to provide 'one-stop' care for CMC.
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By selecting the peptide mimotopes in combination with computational algorithms and site-directed mutagenesis, the epitope of A16 was mapped to the structurally conserved sites located within the β1-α1, loop D, β20-β21 (bridging sheet) and β24-α5 of gp120, which critically determine the CD4 binding and are involved in the epitopes of CD4bs-directed antibodies.
Importantly, this pair of amino acids is located structurally close to the putative binding site.
To be included in the demonstration, a house had to be flooded with < 2 m of water, structurally sound, and located in an area likely to be rebuilt.
An Arf/Arl/Sar co-conserved tryptophan within the C-terminal end of the GTPase domain Trp172-Arf11 in Fig. S2C of Additional File 1) is located structurally near the N-terminal myristate moiety [ 22]--a posttranslational modification implicated in membrane association and a feature required for the biological function of Arf GTPases.
First, we show that most amino acids involved in coevolutionary dynamics are three-dimensionally clustered in the protein structure and closely located to functionally or structurally important sites.
According to the most recent American Society of Civil Engineers' infrastructure report card, one-third of the bridges in the US are rated as structurally deficient and many of these structurally deficient bridges are located in seismic zones.
The results suggest that catalytic residues are usually located in structurally stable environments and the surrounding neighboring residues within 15 Å are also relatively structurally rigid.
The structure-based sequence alignment revealed that most of the structurally invariant residues are located at the carboxy terminus, including the RSL, β1, β2 and α1 of CrSPI-1-D1 (Figure 2).
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