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However, structurally informative fragments are still observed allowing confident identification of the analytes of interest.
This incorporates a permanently charged quaternary ammonium group which increases solubility in reversed-phase solvents, improves ionisation by several orders of magnitude, and directs fragmentation of the sterol backbone to provide structurally informative MS n (MS with multistage fragmentation) spectra.
In addition, this pathway results in transfer of the positive charge from the derivatising group to the sterol backbone, which can then be fragmented further to afford structurally informative fragments in MS spectra.
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The elucidation of the metabolite structure is the most structurally rich and informative end-point in the available range of metabolic assays.
Is information always informative?
When chemical-specific estimates are lacking, the range of interindividual variability for structurally related compounds may be informative, in a read-across approach.
The two moderately informative models are structurally based on the unrestricted heterogeneous variance model and the variance priors are either frequentistic distribution approximations from within the MTC data or distributions previously derived from a large external empirical data set.
One problem concerns the separation of informative optical signal from structurally analogous noise generated by a variety of spurious sources, such as heart beat, respiration, and vasomotor waves.
Structure-based features, while being the most informative, cannot be used to full advantage, as most of the human CYPs are not structurally resolved.
It has also been urged that the definition's obvious circularity is vicious, and that, given the inter-definition of the key concepts (artwork, artworld system, artist, artworld public) it lacks any informative way of distinguishing art institutions systems from other, structurally similar, social institutions (D. Davies, 2004, pp. 248 249, mentions the "commerceworld").
Structurally sound?
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