Sentence examples for structurally important from inspiring English sources

Most known disease-related nsSNPs in proteins of known 3D (three-dimensional) structure appear to affect structurally important residues and sites relevant for function [ 4].

The π π stacking interactions between residues F316 and F367 that are also found in most X-ray structures are likely to be structurally important.

In this work, we developed a neural network approach for identification of structurally important residues from a single protein structure without using homologous structural information and structural alignment.

First, we show that most amino acids involved in coevolutionary dynamics are three-dimensionally clustered in the protein structure and closely located to functionally or structurally important sites.

If there is selection for secondary structures, one may expect higher constraint at structurally important (paired) than at structurally less important (unpaired) sites.

Asn-54 in the 1 4 interface has been shown to have a central role in the structurally important hydrogen-bonding network in the avidin structure [ 17, 26].

Our crystal structure of the PER2-CBD-CRY2 complex unveils a structurally important intermolecular zinc finger, which might function as a stabilizing 'molecular clasp'.

Structurally important positions within the paratope region were identified through stability, structural, and phylogenetic analyses and partially or fully conserved in sequence.

Results of this study are consistent with selection upon mRNA structures: numbers of conserved optimal codons and synonymous substitutions are reduced at structurally important sites.

Previous structural and functional studies of Thermus RPS13 showed that there are two structurally important regions where RPS13 interacts with the 16S rRNA [ 27- 29].

We define protein functions through protein 3D structures, and find that residues converted by RNA editing have significant bias toward structurally important sites.