Short simulation times are sufficient to achieve good refinement of docking poses resulting from exchange of structurally dissimilar inhibitors between crystal structures.
The best hit corresponds to a protein of unknown function from Pseudomonas aeruginosa (PDB ID code 1tu1), presenting a DALI Z-score of 5.9 (Z-scores below 2 are structurally dissimilar) and SSM Q-score of 0.17 (Q = 1 means exact structural alignment) (Figure 8B).
Even when Tri Angle records are structurally dissimilar, they share a fondness for odd noises that skitter through the music.
Yet there are striking examples of TCR recognition of structurally dissimilar ligands.
Nevertheless, the error in prediction on the test set might increase if the compounds present therein were structurally dissimilar.
It is important to see that the duty of assistance to burdened societies is structurally dissimilar from the difference principle.
The NRLiSt BDB datasets of ligands were too large and too structurally dissimilar to be represented by one unique pharmacophore.
In this map/image, the brighter regions depict the areas where the first two frames of the caltrain sequence are structurally dissimilar.
Some of the NRLiSt BDB ligands were structurally dissimilar to all the other ligands of their respective dataset and stood alone in their own cluster.
These dispositions are alleged to be so structurally dissimilar from virtues (as traditionally understood) that it may be psychologically unrealistic to treat (traditional) virtue as a regulative ideal.
Thus, β-arrestins can serve similar regulatory functions for disparate classes of 7TMRs through structurally dissimilar enzymes that degrade chemically distinct second messengers.
