They are structurally disordered, sp2 coordinated and belong to the family of glass-like carbons.
Nevertheless, actors are structurally coupled and coordinated due to systemic and dynamic interdependences, temporally and spatially evolving (Rhodes 1996; Jessop 1998).
In BRDT, the hinge-binding pyrazolo-pyrimidine moiety of dinaciclib binds to the ZA channel through two highly coordinated and structurally conserved water molecules, while the pyridine oxide interacts with the conserved Asn residue (Type ZA).
Each species is so well coordinated, functionally and structurally, that it could not survive significant change.
The PHD1KDM5B structures in both free and bound states adopt a 'cross-braced' topology of zinc ion coordinated residues that was identical to that of all structurally characterized PHD fingers.
The second NEAT domain of IsdB is structurally similar to other heme binding NEAT domains, and heme-iron is coordinated by a tyrosine residue as predicted; however, we have also shown that Met362 coordinates the heme-iron on the distal side, resulting in an unprecedented mode of heme-iron coordination.
This opens the possibility that in acetyltransferases acting on di- and oligosaccharides, the structurally conserved methionine may coordinate the glycosidic bond and thereby fulfill an important role in proper positioning of the acceptor sugar within the active site.
Chemokines are a group of small, structurally related molecules that coordinate the homeostatic circulation of leucocytes.
The ZMM (Zip, Msh, Mer) group of proteins includes seven functionally similar yet structurally diverse proteins that coordinate recombination events and SC formation during meiosis [ 45].
The best known example for structurally-coordinated and functionally-related genes are operons in prokaryotes [ 1].
In addition, 25 E.U. countries signed a fiscal treaty committing them to proactively coordinate budgetary policies and maintain structurally balanced budgets.
