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Next, tests for invariance of first-order factor loadings, second-order factor loadings, and structural variances were conducted.
Main, but not significant, structural variances between 1a and 1b are caused by the presence of different number of crystal water molecules.
However, such predictions are questionable, since structural variances entail different chemical and physicochemical properties.
A review of glycosylated biosimilars approved in the EU and in Japan demonstrates that structural variances exist between biosimilars and their reference products (Table 1).
This table also lists information on the number and kind of indels identified per genome, but does not contain data on structural variances.
This brief report highlights examples of structural variances (i.e., at the level of the drug substance) of biosimilars approved in the European Union (EU) and Japan to illustrate that biosimilarity is not transitive.
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Importantly, none of these cross-links directly involved Rpn12 or were in positions expected to be sterically occluded by Rpn12 based on the pseudoatomic structure of the 26S proteasome, strongly suggesting that these differences resulted from structural variance between the two particles.
Relatively weak spatial dependency associated with structural variance also existed in the direction of NE SW.
The Variance ratio, structural variance as related to sill, and r 2 are presented in Table 2.
The structural variance is correlated with the variance in properties and structure/property maps are produced in the PCA space.
The water content data also showed a low structural variance, which was different in the two years.
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