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Donor site morbidity, such as chronic pain, superficial infection, haematoma and lesions to the lateral femoral cutaneus nerve, has led to an increase in new structural substitutes to a bone graft.
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Therefore, MSCs are actively being considered as candidate cells for the treatment of arthritic joint diseases both as a structural substitute and as a stand-alone cell therapy or as a combination thereof.
Structural and non-structural substitutes of autologous bone grafts are frequently used in hindfoot arthrodeses and osteotomies.
Thus, the primary goal of this systematic review was to assess the efficacy of autologous bone grafts and their structural and non-structural substitutes to achieve union in hindfoot arthrodeses and osteotomies.
The primary goal of this systematic review was to compare autologous bone grafts with structural and non-structural substitutes regarding the odds of union in hindfoot arthrodeses and osteotomies.
In nine [ 4, 51- 58] of the ten included studies rate of union was used as an outcome measure to compare autologous grafts with structural or non-structural substitutes.
Studies eligible for this systematic review had to compare cortical or cancellous autologous bone grafts with any structural or non-structural substitute in patients undergoing subtalar, talonavicular, triple arthrodesis or lateral column lengthening.
CDR's were grafted by structural fit, substituted side-chains were optimised by FASTER algorithm [29] and conjugate gradient minimization.
For 44 substituted phenylureas, the estimation of Koc based on VdW, μ and ELUMO was correct (r = 0.700; Table S7) but the range of experimental data and/or structural differences among substituted phenylureas in terms of substitution on N3 atom was narrow (Reddy and Locke, 1994b).
Our study thus provides further insight into the structural requirements of substituted oxadiazoles for dual inhibition of DNA gyrase and topoisomerase IV.
Five new structural analogues of substituted-1H-quinolinones (19, 20, 23, 24, and 26) have been synthesized and evaluated for Staphylococcus aureus methionyl-tRNA synthetase enzyme inhibitory activity.
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