Our study opens a new avenue in the field and paves the way of the future by permitting a structure-toxicity approach without any structural pre-requisites.
A "world geometry" is a purely mathematical geometry the derived objects of which possess only the structural properties requisite to the ideal of a completely impersonal world; these are objects, as he wrote in Space, Time and Gravitation (1920), a semi-popular best-seller, represented "from the point of view of no one in particular".
General fundamentals and structural and chemical requisites of these architectures are discussed in introduction followed by historical perspectives of the initial composites.
This report describes a theoretical study of the 1,3-dipolar cycloadditions between dimethylvinylborane and different chiral nitrones, aimed at identifying the requisite structural features to achieve high levels of selectivity.
A deeper acyl chain-buried MPER middle section and the elimination of cross-hinge rigid-body motion almost certainly impede requisite structural rearrangements during the fusion process, explaining the absence of MPER AA variants among all known naturally occurring HIV-1 viral sequences.
Given the requisite structural conditions, the new layer invariably appears.
The protein kinase Spc1 is not a requisite structural adaptor or cis-acting regulator for Atf1-promoted recombination when Atf1 is bound to the chromosome (Figure 4).
Furthermore, the Spc1 kinase neither serves as a requisite structural adaptor for Atf1-promoted recombination, nor does it regulate (directly or indirectly) any additional cis- or trans-acting factors required to activate recombination after Atf1 protein becomes bound to the chromosome.
Although most of the studies have been conducted with PbTx-3 (a natural toxin possessing all of the requisite structural characteristics for full activity), the investigators acknowledge that many studies will require repetition for toxins missing one or more activity loci, or for complex mixtures that may include metabolites and antagonists in addition to toxin.
This paper identifies essential structural characteristics and the pre-requisites for fabrication techniques that can yield scaffolds that are capable of directing healthy and homogeneous tissue development.
