Sentence examples for structural rationale from inspiring English sources

This alteration to a key point of interaction with the activators, as evident in the crystal structure, provides a structural rationale for the measured selectivity.

Nonetheless, the accompanying crystal structure paper provides some structural rationale to reconcile the stoichiometry of a Rev hexamer docking to a Crm1 dimer.

The structure-activity relationship analysis provided the structural rationale.

The high-resolution structure of Fsβ-glucanase provides a structural rationale for the different activities obtained from a series of mutant glucanases and a basis for the development of engineered enzymes with increased activity and structural stability.

The lack of a methyl group in the core structure of imipenem may provide a structural rationale for the increase in turnover of this carbapenem by the GES β-lactamases.

The recently determined eubacterial and aracheal OST homologue structures afford an opportunity to glean a structural rationale for the effect of the middle X residue on co- and post-translational N-glycosylation.

Whereas these provided a protein-structural rationale of the activity and stability of globular proteins/enzymes, the point has been neglected that adaptation to extreme temperatures could also have resulted from an increased use of intrinsically disordered proteins (IDPs), which are resistant to these conditions in vitro.

In the present study, we synthesized a bivalent chimeric protein r-Cpae comprising C-terminal binding regions of αC and CPE using structural vaccinology rationale and assessed its protective efficacy against both alpha toxin (αC) and enterotoxin (CPE) respectively, in murine model.

A structural selectivity rationale was used to optimize potency and biopharmaceutical properties and led to the development of a transcriptional inhibitor, 3,4-dimethyl-5-[2- 4-piperazin-1-yl-phenylamino -pyrimidin-4-yl]-3H-thiazol-2-one, with anticancer activity in animal models.

The quality appraisal instrument devised by Philips et al. [ 24] include dimensions of methodological quality corresponding to rationales for structure, structural assumptions, disease states/pathways, cycle length, and internal consistency.

This suggests that the fold code is a network phenomenon along with sequence and structural phenomena, thus providing rationale as to why merely sequence-based or structure-based pattern analysis of proteins may not succeed in decoding fold signatures.