Exact(31)
As logical extension of their secondary-structure counterparts, tertiary structural preferences will likely prove extremely useful in de novo protein design and structure prediction.
Firstly, the structural preferences of ubiquitin conjugation sites preferred structures at ubiquitin conjugation sites must be examined in greater detail because flanking residues are not conserved.
Structural preferences predominantly occur on a secondary structure level.
Comparison of these ensembles and the ensemble of structures previously generated for αS reveals specific differences in the structural preferences of the three proteins and allows the effects of the hydrophobic core on the structural properties of these forms of synuclein, including their different aggregation propensities, to be examined at a molecular level.
However, these methods do not provide information regarding the structural preferences of the protein.
The convex polyhedron, snub dodecahedron (B60H602−, I symmetry) derived from these structural preferences, is a promising candidate for experimental characterization.
Similar(28)
One is the secondary structure information and the other is local structural preference information.
We have derived local structural preference potentials (LSPPs) to capture the structure preference of sequence fragments of short length.
A direct correlation was therefore observed between the surface electronic structure and associated catalytic activity, revealing a pronounced structural preference for (110) and (111) facets (Fig. 7).
By combining the two local structural preference potentials with the widely used sequence profile, secondary structure information and hydrophobic score, we have developed a new threading method called FR-t5 (fold recognition by use of 5 terms).
Here we ask whether FR-t5 which simply incorporates local structural preference information into the three widely used terms (sequence profile, secondary structure and hydrophobic score) can achieve a satisfactory performance that is comparable to the existing popular fold recognition programs.
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