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And then you have in Manhattan and especially in downtown Manhattan all this capital that's kind of flying around and wealthy people enabling certain social and creative and structural initiatives in the cultural landscape.
In planning structural initiatives targeting psychological distress as a public health issue, it is important to avoid those in poorer socio-economic conditions being less involved than those who are better socially positioned.
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PMP is one of the modules of the Nature Protein Structure Initiative (PSI) Structural Biology Knowledgebase (SBKB) (3).
TOPSAN stems from the Protein Structure Initiative (a Structural Genomics project) and was created with the intention of enriching the knowledge of poorly annotated protein structures solved by Structural Genomics projects.
It can be of special interest given the pace of structures production on structural genomic initiatives worldwide, where functional insights can come from discovery of functionally important local structural patterns.
The increasing number of structures available as a result of structural genomic initiatives has generated great interest in the development of structure-based function prediction methods [1], [2].
The realization that sequence alone is not enough to understand/predict function led to the establishment of large structural genomics initiatives where the structure of proteins with low sequence similarity to proteins with known structures were targeted to increase the coverage of fold space and permit more accurate fold recognition, threading and homology modeling (Baker and Sali, 2001).
The cupin superfamily also contains proteins for which the structures are available through world-wide structural genomics initiatives but characterized as "hypothetical".
As international structural genomics initiatives have produced a huge number of structures of unknown function, attempting to automatically assign functions to these proteins is becoming even more necessary, and significant efforts have been devoted to this task [ 5- 8].
The COG2098 family previously was targeted by Structural Genomics Initiatives resulting in the determination of three representative structures: one from Picrophilus torridus (PTO0218; PDB: 2I52), one from M. jannaschii (MJ0408; PDB: 2OGF), and one from Methanopyrus kandleri (MK0786; PDB: 2IEC).
Structural genomics initiatives attempt to infer details of protein function via 3D structure determination (Eisenberg et al. 2000; Shapiro and Harris, 2000).
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