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Elucidating the binding interaction of small bioactive molecules with DNA provides a structural guideline for designing new drugs with improved selectivity and superior clinical efficacy.
Interaction between small molecules and DNA provides a structural guideline in rational drug designing and in the synthesis of new and improved drugs with enhanced selective activity and greater clinical efficacy.
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An idealized WD repeat was designed from a structure-based sequence alignment with a set of structural guidelines.
It offered workshops like "From Once Upon a Time to Happily Ever After: Structural Guidelines for Building a Plot" and "The 16 Hero and Heroine Archetypes".
In a year, additional rules will require abortion facilities to meet the structural guidelines for ambulatory surgical centers, which include wider hallways and preoperative and postoperative waiting rooms.
He has said he would like for that to happen, and the Federal Reserve Bank has announced that it will soon require all major banks to abide by structural guidelines intended to assure that executives are compensated based on performance and that they are not given incentives to take undue risk.
Rubin also created the firm's research report structural guidelines.
The main research objective is to develop structural guidelines for International Organization for Standardization ISOO) shipping containers used for non-shipping applications.
The experimental data suggest that the obtained structural guidelines can be useful tools for the rational design of new potent inhibitors against selected HDAC isoforms.
This confirms the strategy of Blum et al. (2012) combining the B factor with the structure-guided consensus (SGC) concept: they chose WT positions that were not consensus and did not fit a number of structural guidelines and also amino acid positions with a high B factor and replaced them by the consensus amino acid.
53 These findings represented structural guidelines of how NCCs may be oxidized chemically (when functioning as antioxidants).
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