RNAmutants samples mutant sequences and structures according to their probability in the structural ensemble to identify sequences that severely disrupt structure, but fundamentally determines the structural disruption based on the MFE structure of the mutant [ 36].
However, prolines display important differences with the other amino acids because they cause a characteristic structural disruption of secondary structures, and it has been suggested that the abundance of non-contiguous prolines decrease the prionogenicity of a given sequence [ 30].
Since this could indicate either loss of CGRP affinity, absence of receptor expression or severe indirect structural disruption of the receptor structure, these mutants were not analysed further in this study.
Since the algorithm relies on predicted structural disruption, it works especially well where protein structure is known and less reliable when a solved protein structure is not available.
The semantic and structural disruption, starting with the novel's unfinished title, reflects its anarchic intent – to disrupt the comfortably smug, middle-class sensibility personified by Genevieve and her dinner party set, with their stultifying prejudice and snobbery.
Probably PgD5 interacts with essential plasma membrane structures of S. cerevisiae that are not present in C. albicans, causing a structural disruption and alteration of the membrane permeability.
Hypothesized sources of discogenic pain include chronic inflammation, neurovascular ingrowth, and structural disruption.
SEM results revealed the structural disruption of wood sawdust with enzyme incubation.
Furthermore, SEM and FTIR results illustrated the severe structural disruption of seed samples by MILT-MHD.
Scanning electron microscopy demonstrated that structural disruption of tiger nut caused by microwave irradiation was the main reason for rapid extraction.
Typical forms of structural disruption can be reproduced by severe mechanical loading in-vitro, with genetic and age-related weakening sometimes leading to injury under moderate loading.
