This supports the idea that structural discovery is an essential part of human problem-solving.
This study proposes a general framework for structural motif discovery.
This commentary highlights the recent work published in journal Nature on the structural based discovery of novel analgesic compounds for opioid receptors with minimal effects.
We therefore decided not to apply structural variant discovery.
See the review from Medvedev et al. (2009) for the details and strengths of different structural variation discovery methods.
Dissect is suitable for whole transcriptome structural variation discovery problems involving sufficiently long reads or accurately assembled contigs.
In this section, we mathematically formulate these 'conflicts' and model the structural variation discovery problem as a novel combinatorial optimization problem.
In this article, we presented the 'Next-Generation' of our structural variation discovery algorithm VariationHunter that aims to improve both the sensitivity and specificity of SV detection.
The flexibility of frequent itemset mining techniques is demonstrated by the diverse range of bioinformatics problems they have been applied to, including annotation mining, structural motif discovery, subgraph detection, SNP analysis and biclustering of expression profiles.
The alignment tools reviewed above could and have been used for this purpose, but only through the manual curation of the raw alignment output rather than through the use of specialized structural variant discovery tools.
With regard to gapped alignment, it was clearly shown that only 5 aligners lacked the function for SNPs and structural variation discovery, namely, Bowtie, mrsFAST, MAQ, RMAP, and SSAHA2 [ 42].
