Sentence examples for structural destabilization from inspiring English sources

Urea breaks hydrogen bonds among biopolymers leading to structural destabilization.

This enabled us to observe the differential decrease of residual activity among mutants due to structural destabilization during the heat treatment processes.

Metal ions such as Cd2+, Co2+, and Hg2+ act on sulfhydryl residues in proteins and are responsible for a breakdown of disulfide bonds, generally causing a strong inhibitory effect on enzymatic activity by structural destabilization of the protein [34].

Markedly, structural destabilization of the SOD architecture can lead to disease, as mutations in Cu,ZnSOD may result in familial amyotrophic lateral sclerosis, a relatively common, rapidly progressing and fatal neurodegenerative disorder.

Lastly, experimental proof is pending for release of clay-bound N and interlayer NH4+ following reduction of octahedral Fe3+ with consequent increased negative charge or structural destabilization, possibly an important process in floodplain paddy soils in Bangladesh.

Substitution of these residues inevitably causes a structural destabilization of the LRR domain.

This is in agreement with the notion that FMRP dimerization is abolished in a I304N mutant, which causes structural and functional destabilization of the KH2 fold [ 3, 23, 25, 47, 48].

The design of insulin analogues has emphasized stabilization or destabilization of structural elements according to established principles of protein folding.

To explore the clinical significance of repeat location, we engineered a variant of the model protein with a polyQ tract within the domain, a location that does not mimic physiological context, demonstrating significant destabilization and structural perturbation.

Therefore, being able to account for this destabilization in structural and dynamics terms is critical for a mechanistic understanding of base selectivity.

The findings in this study are in accord with a common structural cause for the destabilization of the rNTP-bound post-translocation state and of the pre-translocation state after rNMP incorporation.