Exact(33)
Entries for structural clusters include the cluster representative structure, as well as a consensus sequence, and a list of the structures belonging to the cluster.
The structure of NerA fits to previously proposed structural clusters and also exhibits sequence motifs that allowed prediction of the correct orientation of the residues Y65 and Y356, as well as its monomeric state.
We then define structurally diverse superfamilies as those superfamilies that have at least 2 structural clusters.
Based on a random sample of full-length human mRNAs, we find that the minimum free energy (MFE) structure often poorly represents the Boltzmann ensemble, that the ensemble often contains multiple structural clusters, and that the centroids of a small number of structural clusters more effectively characterize the ensemble.
Hierarchical cluster analysis of mtLSU subassemblies accumulated in mutant strains revealed co-operative assembly of protein sets forming structural clusters and preassembled modules.
The computational technique allows us to produce different structural clusters on the same naturally occurring, packed, stable core but with alternatively connected secondary-structure segments.
Similar(27)
Representative structures were selected for each structural cluster with Tanimoto coefficient (Tc) less than 0.9 to other clusters.
To this effect, it was possible to identify several plausible miRNA clusters with structurally similar stem-loops by performing conventional structural clustering over this reduced set, along with an analysis of their genomic disposition.
Since the "leaves" of this dendrogram correspond to individual configurations, it is possible to complement the dendrogram with color-coded bar plots that represent the value of different properties of each structure, thereby giving a clear picture of the relation between structural clustering and the different properties.
The library was derived from FDA-approved drugs applying data mining and structural clustering techniques.
As a consequence, peptide-bond isomerism plays a less crucial role in determining structural clustering than for the neutral dipeptide.
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