The show's strength, however, is not its one-off stories but its longer arcs, a structural breakthrough of "The X-Files," which modelled the notion that episodic TV could be woven together with powerful, season-long themes, inspiring the more complex breed of modern shows, both sci-fi and regular-fi.
He does note the odd structural breakthrough and points out flaws in his earlier work, but pointedly he also says this: "Writers feel threatened by biography, their lives as they see it are what they have put in the shop window, the rest – what's in the back place – their business".
Structural biology offers breakthroughs for key issues in receptors, ion channels and transporters.
Indeed, the availability of prokaryotic homologs has resulted in structural and functional breakthroughs in the related field of rhomboid [42], [43], [44], [45] and S2P [46] intramembrane proteases.
Going beyond the limits of existing systems requires structural innovation and breakthrough solutions to enhance their design and performance.
Although the breakthrough structural information about LeuT [10] [15], and about some other related transporters [17] [19] is recent, a number of models have been proposed for the functional mechanism of LeuT and cognate NSS transporters.
Solid-state NMR spectroscopy (SSNMR) has granted breakthroughs in structural investigations on amyloid fibrils ranging from the assessment of the impact of polymorphism in disease development to the 3D atomic structure determination of amyloid fibrils.
Here, we summarize recent breakthroughs in structural studies of bacterial MraYs and the closely related human GPT (UDP-N-acetylglucosamine: dolichyl phosphate N-acetylglucosamine-1-phosphate transferase or GlcNAc-1-P-transferase).
