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Though the α-helical part typical of POTRA domains is missing, the residual structure is similar with key residues conserved among SPATEs forming the structural backbone.
Sphingolipids comprise a large family of lipids, which differs structurally from other lipid species by containing a sphingoid base as structural backbone.
In the 1980s, NASA challenged Lockheed Martin to cut the weight of the huge fuel tank that forms the structural backbone of the space shuttle by several thousand pounds.
They then removed the rod and stretched the coil to create a strong spring, about a millimeter in diameter, to serve as both the battery's structural backbone and its anode.
Exceptional structural features of this class of heterocycle and versatile biological applications made it a privileged structural backbone in new drug design and discovery.
As the structural backbone of blood clots, fibrin networks carry out the mechanical task of stemming blood flow at sites of vascular injury.
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There are two major types for the structural "backbones" of clay minerals called silicate layers.
Claudins represent the structural backbones of tight junctions [ 14] and have distinctive functions, such as ensuring cell adhesion.
Greater knowledge of apolipoproteins (proteins that bind lipids and that function both as structural backbones of lipoprotein particles and as regulators of cellular lipid import and export) will prove to be invaluable to our understanding of lipoprotein function.
From the data collected, it is important to note again that not only are there two structural backbones for the brevetoxin molecules, but there are at least 13 different derivatives thereof, and each of these derivatives possesses a specific toxicity that is correlated to its binding affinity on VSSCs.
Furthermore, characterization of lipoprotein biology is impeded without a comprehensive study of apolipoproteins, the class of over a dozen secreted, lipid-binding proteins that function as structural backbones of lipoprotein particles and regulators of cellular lipid flux through their interactions with cell surface receptors.
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